E-ISSN: 1308-5263
The Role of Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma [Turk J Hematol]
Turk J Hematol. Ahead of Print: TJH-01700 | DOI: 10.4274/tjh.galenos.2019.2018.0420  

The Role of Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma

Bülent Saka1, Müge Sayitoğlu2, Zülal İstemihan1, M. Akif Karan1, Nilgün Erten1, Öner Doğan3, Uğur Özbek2, Sema Genç4, Cemil Taşcıoğlu1, Sevgi Kalayoğlu Beşışık1
1Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University, Turkey
2Department of Genetics, Aziz Sancar Institute of Experimental Research, Turkey
3Department of Pathology, Istanbul Faculty of Medicine Istanbul University, Turkey
4Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Turkey

Objective: Angiotensin II acts as a growth promoter or angiogenic factor via type 1 receptors (AGTR1) in certain tumors.
Materials and Methods: In this study, we examined the bone marrow AGTR1 expression in multiple myeloma (MM) and its relationship with the regulation of angiogenesis and prognostic factors. Bone marrow AGTR1 mRNA levels of 39 MM patients and 15 healthy controls were analysed with quantitative RT-PCR. Bone marrow angiogenesis was evaluated with immunohistochemical measurement of tissue vascular endothelial growth factor (VEGF), CD34 and factor VIIIrAg (fVIIIrAg).
Results: Patients had higher bone marrow VEGF, fVIIIAg, CD34 and AGTR1 expression levels when compared to controls, and patients with severe-diffuse bone marrow infiltration showed higher bone marrow VEGF, fVIIIAg, CD34 and AGTR1 mRNA levels when compared to other patients.
Conclusion: AGTR1 expression was found positively correlated with plasma beta-2 microglobulin level and patients with increased AGTR1 expression showed increased bone marrow CD34 levels.

Keywords: Multiple myeloma, renin-angiotensin system, angiotensin type 1a receptor




Corresponding Author: Bülent Saka, Türkiye


TOOLS
Uncorrected Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar


 



Impact Factor (2017) = 0.650