Secondary Neoplasms in Children with Hodgkin’s Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four CasesSevgi Gözdaşoğlu1, Ali Pamir1, Emel Ünal1, İsmail Haluk Gökçora2, Ömer Uluoğlu3, Koray Ceyhan4, Haluk Deda5, Erdoğan Işıkman6, Gülsan Yavuz1, Nurdan Taçyıldız1, Ayhan Çavdar11Ankara University Faculty of Medicine, Department of Pediatric Hematology and Oncology, Ankara, Turkey
2Ankara University Faculty of Medicine, Department of Pediatric Surgery, Ankara, Turkey
3Gazi University Faculty of Medicine, Department of Pathology, Ankara, Turkey
4Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey
5TOBB University of Economics and Technology Hospital, Clinic of Neurosurgery, Ankara, Turkey
6Ankara University Faculty of Medicine, Department of Radiotherapy, Ankara, Turkey
Patients who survive Hodgkin lymphoma (HL) are at increased risk of secondary neoplasms (SNs). A wide variety of SNs have been reported, including leukemias, non-Hodgkin’s lymphomas, and solid tumors, specifically breast and thyroid cancers. Herein we report subsequent neoplasms in four patients with HL receiving chemoradiotherapy. It is interesting that three SNs, fibrosarcoma, thyroid carcinoma, and retrobulbar meningioma, were observed in the radiation area in one of our patients. A hypopharyngeal epithelioid malignant peripheral nerve sheath tumor as an unusual secondary malignant neoplasm developed in another patient, while a benign thyroid nodule and invasive ductal breast carcinoma were observed at different times in the female patient. Follicular adenoma of the thyroid gland developed in one of our patients. Keywords: Secondary neoplasms, Chemoradiotherapy, Hodgkin’s lymphoma
C-MOPP ve Radyoterapi Alan Hodgkin Lenfomalı Çocuklarda İkincil Neoplaziler: Dört Olgu SunumuSevgi Gözdaşoğlu1, Ali Pamir1, Emel Ünal1, İsmail Haluk Gökçora2, Ömer Uluoğlu3, Koray Ceyhan4, Haluk Deda5, Erdoğan Işıkman6, Gülsan Yavuz1, Nurdan Taçyıldız1, Ayhan Çavdar11Ankara University Faculty of Medicine, Department of Pediatric Hematology and Oncology, Ankara, Turkey
2Ankara University Faculty of Medicine, Department of Pediatric Surgery, Ankara, Turkey
3Gazi University Faculty of Medicine, Department of Pathology, Ankara, Turkey
4Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey
5TOBB University of Economics and Technology Hospital, Clinic of Neurosurgery, Ankara, Turkey
6Ankara University Faculty of Medicine, Department of Radiotherapy, Ankara, Turkey
Yaşayan Hodgkin lenfomalı olgularda ikincil neoplazilerin gelişme riski yüksektir. Lösemiler, Hodgkin-dışı malign lenfomalar ve solid tümörler özellikle meme ve tiroid kanserlerini içeren çok çeşitli ikincil malign neoplaziler raporlanmıştır. Burada kemoradyoterapi alan Hodgkin lenfomalı dört olguda gelişen ikincil neoplaziler sunulmuştur. İlginç olarak hastalarımızdan birinde ışın alanında üç ikincil neoplazm; fibrosarkom, tiroid karsinom ve retrobulber meningiom, diğer bir hastamızda sıradışı ikincil malign neoplazm olarak hipofaringeal epitelyal malign periferik sinir kılıfı tümörü gelişirken kız hastada farklı zamanlarda benign tiroid nodülü ve invaziv duktal meme kanseri saptandı. Bir hastamızda ise, tiroidde folliküler adenoma gelişti. Anahtar Kelimeler: İkincil neoplaziler, Kemoradyoterapi, Hodgkin lenfoması
Sevgi Gözdaşoğlu, Ali Pamir, Emel Ünal, İsmail Haluk Gökçora, Ömer Uluoğlu, Koray Ceyhan, Haluk Deda, Erdoğan Işıkman, Gülsan Yavuz, Nurdan Taçyıldız, Ayhan Çavdar. Secondary Neoplasms in Children with Hodgkin’s Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases. Turk J Hematol. 2016; 33(1): 66-70
Corresponding Author: Sevgi Gözdaşoğlu, Türkiye |
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