Platelet Labeling for Determination of LifespanEmilian Mladeimov1, Susanne Granegger1, Stephan Hann2, Helmut Sinzinger31Working Group Of Analytical Chemistry, Institute Of Chemistry, University Of Agricultural Sciences, Vienna, Austria
2Department Of Nuclear Medicine, University Of Vienna, Austria
3Wilhelm Auerswald Atherosclerosis Research Group (ASF), Veinna, Austria
After various earlier attempts with different radiotracers 51chromium and finally ^IndiumoKİne became the tracers of choice for the radiolabeling of human platelets and the subsequent monitoring of in vivo kinetics. Data on clinical application of platelet survival in atherosclerotic vascular disease and a variety of risk factors are presented. Furthermore, a new approach to use nonradioactive material (rubidium) as label for platelets allowing application in children and pregnants, where only the information on platelet survival is necessary, are discussed. The application of 111lndium-oxine and cold rubidium is an underused reiiable methodology for the assessment of lifespan of human platelets for clinical diagnosis and treatment monitoring. Keywords: Platelet survival, Plateiet radiolabeling, 11 ] ln-oxine, Rubidium, Atherosclerosis, in vivo platelet functîon.
Emilian Mladeimov, Susanne Granegger, Stephan Hann, Helmut Sinzinger. Platelet Labeling for Determination of Lifespan. Turk J Hematol. 2002; 19(2): 275-281
Corresponding Author: Helmut Sinzinger, Austria |
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