The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical SignificanceŞadiye Mehtat Ünlü1, Hayri Özsan2, Sülen Sarıoğlu11Dokuz Eylül University Faculty of Medicine, Department of Pathology, İzmir, Turkey
2Dokuz Eylül University Faculty of Medicine, Department of Hematology, İzmir, Turkey
Multiple myeloma (MM) is one of the most important clonal malignant plasma cell disorders and renal involvement is associated with poor prognosis. Although there are several reasons for renal impairment in MM, the main cause is the toxic effects of monoclonal proteins. Although cast nephropathy is the best known and unchallenged diagnosis for hematologists and pathologists, the renal effects of monoclonal gammopathy can be various. Monoclonal gammopathy of renal significance was proposed by the International Kidney and Monoclonal Gammopathy Research Group for renal lesions in monoclonal gammopathy in recent years. Renal lesions in monoclonal gammopathy can be grouped as follows: light chain (cast) nephropathy, acute tubular injury/necrosis, tubulointerstitial nephritis, amyloidosis, monoclonal Ig deposition diseases, immunotactoid glomerulopathy, type I cryoglobulinemia, proliferative glomerulonephritis with monoclonal IgG deposits, C3 glomerulopathy with monoclonal gammopathy, and crystal-storing histiocytosis, considering the previous and new terminology. In this study, renal involvement of monoclonal gammopathies, in terms of previous and new terminology, was reviewed. Keywords: Monoclonal gammopathy of renal significance, Plasma cell disorders, Multiple myeloma, Renal involvement, Kidney, Cast nephropathy
Monoclonal Gammopatilerin Her Klinik Evresinde Böbrek Etkilenim PaternleriŞadiye Mehtat Ünlü1, Hayri Özsan2, Sülen Sarıoğlu11Dokuz Eylül University Faculty of Medicine, Department of Pathology, İzmir, Turkey
2Dokuz Eylül University Faculty of Medicine, Department of Hematology, İzmir, Turkey
Multipl miyelom (MM) malign plazma hücre hastalıklarının en önemlilerinden biridir ve böbrek tutulumu kötü prognozla ilişkilidir. Multipl miyelomda böbrek fonksiyonunu etkileyecek çeşitli faktörler bulunmakla birlikte ana etken monoklonal proteinlerin toksik etkisidir. Monoklonal gammopatilerde böbrek tutulumları içinde hematolog ve patologlar tarafından en iyi bilinen ve tanısı sorunsuz olan “kast nefropatisi” olmakla birlikte çok farklı tutulum tipleri olabilir. Yakın zamanda “International Kidney and Monoclonal Gammopathy Research Group” tarafından, monoklonal gammopatilerdeki böbrek tutulumlarını bir çatı altında toplayan “renal öneme sahip monoklonal gammopati” terimi önerildi. Monoklonal gammopatilerdeki böbrek lezyonları, önceki ve yeni terminoloji uyarınca; hafif zincir kast nefropati, akut tübüler zedelenme/nekroz, tubulointerstisyel nefrit, amiloidoz, monoklonal Ig depo hastalıkları, immünotaktoid glomerülopati, tip I kriyoglobulinemi, monoklonal IgG depoziti ilişkili proliferatif glomerülonefrit, monoklonal gammopati ilişkili C3 glomerülopati ve kristal/histiyosit depo hastalığı olarak gruplanabilir. Bu makalede, monoklonal gammopatilerdeki böbrek tutulumu yeni ve önceki terminolojiler gözden geçirildi. Anahtar Kelimeler: Renal öneme sahip monoklonal gammopati, Plazma hücre hastalıkları, Multipl miyelom, Böbrek tutulumu, Böbrek, Kast nefropati
Şadiye Mehtat Ünlü, Hayri Özsan, Sülen Sarıoğlu. The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance. Turk J Hematol. 2017; 34(4): 282-288
Corresponding Author: Şadiye Mehtat Ünlü, Türkiye |
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