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Usage of U7 snRNA in gene therapy of hemoglobin S disorder - is it feasible? [Turk J Hematol]
| Turk J Hematol. 2009; 26(3): 159-160
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Usage of U7 snRNA in gene therapy of hemoglobin S disorder - is it feasible?Viroj WiwanitkitWiwanitkit House, Bangkhae, 10160 Bangkok, Thailand
OBJECTIVE: OBJECTIVE: Hemoglobin (Hb) S disorder [beta6(A3)Glu-->Val, GAG-->GTG] is an important hemoglobinopathy with the highest endemicity in Africa.
METHODS: METHODS: Here, the author performs a basic bioinformatics gene ontology study to assess the effect of co-expression between nucleic acid sequence for human Hb S beta globin chain and U7.623.
RESULTS: : According to this study, the analytical results show that fully recovery of hemoglobin in both function and biological process can be got.
CONCLUSION: CONCLUSION: Here, the author proposed that U7 snRNA might be a probable tool for treatment by gene therapy approach in Hb S disorder.
Keywords: hemoglobin S, U7 snRNA
Hemoglobin S hastalığının gen tedavisinde U7 snRNA kullanımı uygun mu?Viroj WiwanitkitWiwanitkit House, Bangkhae, 10160 Bangkok, Thailand
Viroj Wiwanitkit. Usage of U7 snRNA in gene therapy of hemoglobin S disorder - is it feasible?. Turk J Hematol. 2009; 26(3): 159-160
Corresponding Author: Viroj Wiwanitkit, Thailand |
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