T102C polymorphism of the serotonin (5-HT) 2A receptor gene in Turkish children with cerebral infarctBuket Nebiye Dönmez1, Serap Teber2, Gülhis Deda2, Nejat Akar31Biotechnology Institute Of Ankara University, Ankara, Turkey
2Department Of Pediatric Neurology, Ankara University, Faculty Of Medicine, Ankara, Turkey
3Department Of Pediatric Molecular Genetics, Ankara University, Faculty Of Medicine, Ankara, Turkey
Platelet-dependent thromboembolism is an underlying mechanism in the pathogenesis of stroke. 5-HT2A receptor gene is expressed in human platelet, coronary artery (blood vessels) and brain. A polymorphism T102C at the 5-HT2A receptor gene was found that may possibly affect the 5-HT2A receptor function. As there is no existing data on T102C variant of 5-HT2A receptor gene in pediatric stroke, we aimed to study in this case-control study whether there is a association between this polymorphism and pediatric stroke. 111 patients (10 months-18 years old) with cerebral infarct and 79 healthy control was included to our study. Polymerase chain reaction (PCR) of the T102C alteration at the 5-HT 2A receptor gene was performed. Our data revealed that, 5-HT (2A) receptor T102C polymo phism was not associated with pediatric stroke in our population either alone or in combination with underlying pro thrombotic factors. However, this needs to be clarified with further studies. Keywords: Pediatric stroke, 5-HT 2A receptor gene, T102C polymorphism
Serebral infarktlı Türk çocuklarında seratonin (5-HT) 2A reseptör genindeki T102C polimorfizmiBuket Nebiye Dönmez1, Serap Teber2, Gülhis Deda2, Nejat Akar31Biotechnology Institute Of Ankara University, Ankara
2Department Of Pediatric Neurology, Ankara University, Faculty Of Medicine, Ankara
3Department Of Pediatric Molecular Genetics, Ankara University, Faculty Of Medicine, Ankara
5-HT2A reseptör genindeki T102C polimorfizmi muhtemelen bu reseptörün fonksiyonlarını etkilemektedir. Pediatrik inmede 5-HT2A reseptör genindeki T102C varyantı ile ilgili mevcut bilgi olmadığı için çalışmamızda; bu polimorfizm ile pediatrik inme arasında ilişki olup olmadığını araştırmayı amaçladık. Serebral inme öyküsü olan 111 çocuk (10 ay-18 yaş) ve 79 sağlıklı kontrol çalışmaya dâhil edildi. 5-HT2A reseptör genindeki T102C değişimi PCR tekniği ile çalışıldı. Sonuç olarak; bu polimorfizm ne tek başına ne de diğer altta yatan protrombotik faktörlerle birlikte değerlendirildiğinde pediatrik inme ile ilişkili bulunmadı, ne var ki bu bilgi daha sonraki çalışmalarla da aydınlatılmalıdır. Anahtar Kelimeler: Pediatrik inme, 5-HT 2A reseptör geni, T102C polimorfizmi
Buket Nebiye Dönmez, Serap Teber, Gülhis Deda, Nejat Akar. T102C polymorphism of the serotonin (5-HT) 2A receptor gene in Turkish children with cerebral infarct. Turk J Hematol. 2007; 24(1): 14-17
Corresponding Author: Serap Teber, Türkiye |
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