Agranulocytosis: A Rare Complication of Infectious Mononucleosis and Recovery After IVIG TherapyAkgün Ölmez1, Fatma Gümrük2, Mehmet Ceyhan3, İlhan Tezcan41Department Of Pediatric, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
2Department Of Pediatric Hematology, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
3Department Of Pediatric Infectious Diseases, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
4Department Of Pediatric Immunology, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
A six-year-old boy was admitted with acute agranulocytosis four weeks after the onset of infectious mononucleosis. His bone marrow aspiration revealed maturation arrest of myeloid series. He was hospitalized for agranulocytosis and he was put on intravenous immunoglobulin (IVIG) (400 mg/kg/day) on the third day of hospitalization for two days. His white blood cell count increased to 4200/mm3 (1176 PMNL absolutely) on the fifth day. This may suggest that IVIG therapy may be effective for early recovery from agranulocytosis which is a very rare complication of infectious mononucleosis. Keywords: Agranulocytosis, Infectious mononucleosis, intravenous immunoglobuline therapy.
İnfeksiyöz Mononükleozun Nadir Görülen Bir Komplikasyonu Olarak Agranülositoz ve IVIG Tedavisi ile DüzelmeAkgün Ölmez1, Fatma Gümrük2, Mehmet Ceyhan3, İlhan Tezcan41Department Of Pediatric, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
2Department Of Pediatric Hematology, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
3Department Of Pediatric Infectious Diseases, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
4Department Of Pediatric Immunology, Hacettepe University Faculty Of Medicine, İhsan Doğramacı Children’s Hospital, Ankara, Turkey
Altı yaşında bir erkek çocuk, infeksiyöz mononükleozun başlangıcından dört hafta sonra akut agranülositoz ile hastaneye getirildi. Kemik iliği aspirasyonu miyeloid seride maturasyon duraklaması gösterdi. Hastaneye yatırılan hastaya, yatışının üçüncü günü, iki gün süre ile intravenöz immünglobulin (400 mg/kg/gün) başlandı. Beyaz küre sayısı beşinci gün 4200/mm3 (PMNL: 1176/mm3)’e yükseldi. Bu da intravenöz immünglobulinin infeksiyöz mononükleozun nadir komplikayonlarından biri olan agranülositozda etkili olabileceğini göstermektedir. Anahtar Kelimeler: Agranülositoz, Ý, nfeksiyöz mononükleoz, intravenöz immünglobulin. Turk J Haematol
Akgün Ölmez, Fatma Gümrük, Mehmet Ceyhan, İlhan Tezcan. Agranulocytosis: A Rare Complication of Infectious Mononucleosis and Recovery After IVIG Therapy. Turk J Hematol. 2003; 20(2): 91-93
Corresponding Author: Akgün Ölmez, Türkiye |
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