Turk J Hematol. 2004; 21(1): 27-32

Anti-D and Intravenous Immunoglobulin Treatments in Chronic Idiopathic Thrombocytopenic Purpura

Çağatay Ünsal¹, Emel Gürkan¹, Birol Güvenç¹, Fikri Başlamışlı¹, Abdullah Canataroğlu^2
1Division Of Haematology, Department Of Internal Medicine, Çukurova University Medical Faculty, Adana, Turkey
²Division Of Rheumatology-ımmunology, Department Of Internal Medicine, Çukurova University Medical Faculty, Adana, Turkey

The aim of this prospective study was to evaluate the data from 29 patients diagnosed as chronic refractory idiopathic thrombocytopenic purpura (ITP) treated with anti-D immunoglobulin and intravenous immunoglobulin G (IVIG). We used anti-D and IVIG in 11 and 18 patients respectively in whom the previous treatments including corticosteroids and splenectomy had been unsuccessful. The complete response rates were significantly higher in IVIG arm (55.5% to 18.1%) with a duration of 8 weeks. The overall efficacy of IVIG in the chronic ITP is similar to previous data, however we found lower platelet responses in patients treated with anti-D that can be attributed to the lower sucess in the splenectomized patients.

Keywords: Anti-D, Intravenous immunoglobulin, Idiopathic thrombocytopenic purpura.

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Kronik İdiyopatik Trombositopenik Purpurada Anti-D ve İntravenöz İmmünglobulin Tedavisi

Çağatay Ünsal¹, Emel Gürkan¹, Birol Güvenç¹, Fikri Başlamışlı¹, Abdullah Canataroğlu^2
1Division Of Haematology, Department Of Internal Medicine, Çukurova University Medical Faculty, Adana, Turkey
²Division Of Rheumatology-ımmunology, Department Of Internal Medicine, Çukurova University Medical Faculty, Adana, Turkey

Bu prospektif çalışlmada anti-D immünglobulin ve intravenöz immünglobulin (IVIG) tedavisi alan 29 hastanın verisi incelenmişltir. Daha önceki kortikosteroid ve splenektomi yaklaşımları başlarısız olan 11 hastada anti-D, 18 hastada ise IVIG kullanıldı. IVIG kolunda tam yanıt oranları yüksek iken (%55`e karflı %18.1), süre 8 hafta idi. Genel olarak kronik idiyopatik trombositopenik purpurada IVIG başlarısı daha önceki verilerle benzer iken, anti-D immünglobulin alan grupta trombosit yanıtını daha düşlük bulduk.

Anahtar Kelimeler: Anti-D, İntravenöz immünglobulin, İdiyopatik trombositopenik purpura.

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