Turk J Hematol. 2002; 19(2): 275-281

Platelet Labeling for Determination of Lifespan

Emilian Mladeimov¹, Susanne Granegger¹, Stephan Hann², Helmut Sinzinger^3
1Working Group Of Analytical Chemistry, Institute Of Chemistry, University Of Agricultural Sciences, Vienna, Austria
²Department Of Nuclear Medicine, University Of Vienna, Austria
³Wilhelm Auerswald Atherosclerosis Research Group (ASF), Veinna, Austria

After various earlier attempts with different radiotracers 51chromium and finally ^IndiumoKİne became the tracers of choice for the radiolabeling of human platelets and the subsequent monitoring of in vivo kinetics. Data on clinical application of platelet survival in atherosclerotic vascular disease and a variety of risk factors are presented. Furthermore, a new approach to use nonradioactive material (rubidium) as label for platelets allowing application in children and pregnants, where only the information on platelet survival is necessary, are discussed. The application of 111lndium-oxine and cold rubidium is an underused reiiable methodology for the assessment of lifespan of human platelets for clinical diagnosis and treatment monitoring.

Keywords: Platelet survival, Plateiet radiolabeling, 11 ] ln-oxine, Rubidium, Atherosclerosis, in vivo platelet functîon.

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