Turk J Hematol. 2014; 31(3): 261-265 | DOI: 10.4274/Tjh.2013.0003

The Evaluation of Hydroxyethyl Starch (6% HES 130/0.4) Solution’s Potential Preventive Effects on Coagulation Status in Women with Gynecologic Malignancies Using Rotation Thromboelastography

Meltem Olga Akay¹, Ayten Bilir², Tufan Öge³, Gökhan Kuş¹, Fezan Şahin Mutlu^4
1Eskişehir Osmangazi University Faculty Of Medicine, Department Of Hematology, Eskişehir, Turkey
²Eskişehir Osmangazi University Faculty Of Medicine, Department Of Anesthesiology And Reanimation, Eskişehir, Turkey
³Eskişehir Osmangazi University Faculty Of Medicine, Department Of Obstetrics And Gynecology, Eskişehir, Turkey
⁴Eskişehir Osmangazi University Faculty Of Medicine, Department Of Biostatistics, Eskişehir, Turkey

OBJECTIVE: The aim of this study was to determine the effects of in vitro hemodilution with 6% hydroxyethyl starch (HES) 130/0.4 solution on the coagulation status of women with gynecologic malignancies by using rotation thromboelastogram (ROTEM®).
METHODS: Twenty-two patients with gynecological tumors scheduled for anesthesia were enrolled. Blood
samples were diluted by 20% with 6% HES (130/0.4) solution.
RESULTS: In the INTEM assay, clotting time (CT) (p<0.01) and clot formation time (CFT) (p<0.001) were significantly increased and maximum maximum clot formation (MCF) (p< 0.001) was significantly decreased in HES hemodilution compared with the undiluted control samples. In the EXTEM assay, there was a similar significant increase in increase in CFT (p<0.01) and a decrease in maximum a decrease in MCF (p<0.01) in HES hemodilution when compared with control samples.
CONCLUSION: HES 130/0.4 solution causes significant hypocoagulable changes in the thromboelastographic profile of gynecologic cancer patients in vitro.

Keywords: Blood coagulation, Colloids, Genital neoplasms, Thromboelastography

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Jinekolojik Maligniteli Kadınlarda Hidroksietil Nişasta (%6 HES 130/0.4) Solüsyonunun Potansiyel Koruyucu Etkilerinin Rotasyonel Trombelastografi Kullanılarak Değerlendirilmesi

Meltem Olga Akay¹, Ayten Bilir², Tufan Öge³, Gökhan Kuş¹, Fezan Şahin Mutlu^4
1Eskişehir Osmangazi University Faculty Of Medicine, Department Of Hematology, Eskişehir, Turkey
²Eskişehir Osmangazi University Faculty Of Medicine, Department Of Anesthesiology And Reanimation, Eskişehir, Turkey
³Eskişehir Osmangazi University Faculty Of Medicine, Department Of Obstetrics And Gynecology, Eskişehir, Turkey
⁴Eskişehir Osmangazi University Faculty Of Medicine, Department Of Biostatistics, Eskişehir, Turkey

AMAÇ: Bu çalışmanın amacı, jinekolojik maligniteli kadınlarda %6 hidroksietil nişasta (HES) 130/0,4 solüsyonu ile hemodilüsyonun koagülasyon durumu üzerine in vitro etkilerinin rotasyonel trombelastogram (ROTEM®) kullanarak belirlenmesidir.
YÖNTEMLER: Anestezi programına alınan jinekolojik tümörlü 22 hasta dahil edildi. Kan örnekleri %6 HES (130/0,4) solüsyonu ile %20 dilue edildi.
BULGULAR: INTEM analizinde, HES hemodilüsyonunda, dilüsyon yapılmayan kontrol örneklerine göre pıhtılaşma zamanı (CT) (p<0.01) ve pıhtı oluşma zamanı (CFT) (p<0,001) anlamlı uzamış ve maksimum pıhtı sertliği (MCF) (p<0,001) anlamlı kısalmış idi. EXTEM analizinde, HES hemodilüsyonunda, dilüsyon yapılmayan kontrol örneklerine göre benzer olarak CFT değerinde anlamlı uzama (p<0,01) ve MCF değerinde anlamlı kısalma (p<0,01) mevcut idi.
SONUÇ: HES 130/0,4 solüsyonu jinelolojik kanserli hastaların trombelastografik profilinde in vitro önemli hipokoagulabl değişikliklere yol açmaktadır.

Anahtar Kelimeler: Kan koagülasyonu, Kolloidler, Genital neoplaziler, Trombelastografi

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