Turk J Hematol. 2020; 37(1): 1-4 | DOI: 10.4274/tjh.galenos.2019.2019.0157

Acute Graft-Versus-Host Disease: A Brief Review

Elifcan Aladağ¹, Engin Kelkitli², Hakan Göker^1
1Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey
²Ondokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, Turkey

Graft‐versus‐host disease (GvHD) is an important complication that can be observed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Acute GvHD (aGvHD) is seen after alloHSCT and the incidence of aGvHD is around 30%-50%. aGvHD prophylaxis is essential in patients undergoing allo-HSCT. Initial therapy for aGvHD is steroids. Prognosis is poor in aGvHD patients not responding to steroids. In this article, the pathobiology, clinical findings, prophylaxis, and treatment of aGvHD will be summarized.

Keywords: Graft-versus-host disease, Acute, Chroni

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Akut Graft Versus Host Hastalığı: Kısa Bir Derleme

Elifcan Aladağ¹, Engin Kelkitli², Hakan Göker^1
1Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey
²Ondokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, Turkey

Akut graft‐versus‐host hastalığı (GvHD), allojeneik hematopoetik kök hücre nakli (alloHKHN) sonrasında görülebilen önemli bir komplikasyondur. Akut GvHD (aGvHD) insidansı yaklaşık %30-50 oranında görülmektedir. AlloHKHN yapılan hastalarda GvHD proflaksisi önemlidir. aGvHD gelişen hastalarda başlangıç tedavisi steroiddir. Steroide yanıtsız aGvHD’de prognoz kötüdür. Bu yazıda aGvHD patobiyolojisi, klinik bulguları, profilaksisi ve tedavisi özetlenecektir.

Anahtar Kelimeler: Graft‐, versus‐host hastalığı, Akut, Kronik

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