Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma:  A Case Report and Review of the Literature

Karata�, Sonay G�ven; Bayrak, Reyhan; Bal��k, �zlem �ahin; Yal��n, Kadir Serkan; At�c�, Esra; Aky�ld�z, �mit; Ko�ar, Ali

Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature [Turk J Hematol]

Turk J Hematol. 2013; 30(1): 67-71 | DOI: 10.4274/tjh.53215

Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature

Sonay G�ven Karata�¹, Reyhan Bayrak², �zlem �ahin Bal��k³, Kadir Serkan Yal��n¹, Esra At�c�¹, �mit Aky�ld�z¹, Ali Ko�ar³
¹Turgut �zal University, School Of Medicine, Department Of Internal Medicine, Ankara, Turkey
²Turgut �zal University, School Of Medicine, Department Of Pathology, Ankara, Turkey
³Turgut �zal University, School Of Medicine, Department Of Hematology, Ankara, Turkey

Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that presents with serosal effusion in body cavities, without obvious tumor masses. Although PEL occurs in immunocompromised patients that are human immunodeficiency virus (HIV) positive, it also occurs in immunocompetent human herpes virus-8 (HHV-8)-positive patients. Herein we present an immunocompetent, HIV-negative, CD-20-negative, HHV-8-positive patient with pleural effusion that was diagnosed as PEL. The CHOP protocol and talc pleurodesis were administered. HHV-8 plays a causative role in PEL and is important for differentiating PEL from other types of lymphoma. As such, in addition to pleurodesis antiviral treatment should be considered for optimal treatment outcome.

Keywords: Differential diagnosis, Human herpes virus-8, Human immunodeficiency virus (HIV), Pleural effusion, Primary effusion lymphoma

�nsan Ba��kl�k Yetmezlik Vir�s� (HIV) Negatif Human Herpes Virus-8 (HHV- 8) Pozitif Primer Ef�zyon Lenfoma Olgusu ve Literat�r Derlemesi

Sonay G�ven Karata�¹, Reyhan Bayrak², �zlem �ahin Bal��k³, Kadir Serkan Yal��n¹, Esra At�c�¹, �mit Aky�ld�z¹, Ali Ko�ar³
¹Turgut �zal �niversitesi T�p Fak�ltesi, �� Hastal�klar� Anabilim Dal�, Ankara, T�rkiye
²Turgut �zal �niversitesi, T�p Fak�ltesi, Patoloji Anabilim Dal�, Ankara, T�rkiye
³Turgut �zal �niversitesi, T�p Fak�ltesi, Hematoloji Bilim Dal�, Ankara, T�rkiye

Primer ef�zyon lenfomas� (PEL) v�cut bo�luklar�ndaki ser�z zarlarda t�m�r kitlesi olmaks�z�n, sadece serozal eff�zyonla karakterize, nadir g�r�len bir hodgkin d�� lenfomad�r. PEL imm�nsupresif ve �zellikle HIV pozitif olgularda g�r�lmekle birlikte Human herpes virus-8 (HHV-8) pozitif imm�n sistemi sa�lam olgularda da tespit edilmektedir. Bu olguda imm�nkompetan, HIV negatif, plevral eff�zyonu olan HHV-8 pozitif, primer eff�zyon lenfomal� erkek hasta sunulacakt�r. HHV-8 pozitif CD-20 negatif PEL olgumuzda tedavide CHOP protokol� ve talk pl�rodezis uyguland�. HHV-8 pozitifli�i PEL tan� ve ay�r�c� tan�s�nda �nemli role sahiptir. Bu y�zden, PEL tedavisinde pl�rodezise ek olarak antiviral tedavinin uygulanmas�yla ba�ar�l� sonu�lar elde edilebilece�i d��n�lmektedir.

Anahtar Kelimeler: Ay�r�c� tan�, Human herpes vir�s-8, Human immunodeficiency virus (HIV), Plevral ef�zyon, Primer Ef�zyon Lenfomas�

Sonay G�ven Karata�, Reyhan Bayrak, �zlem �ahin Bal��k, Kadir Serkan Yal��n, Esra At�c�, �mit Aky�ld�z, Ali Ko�ar. Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature. Turk J Hematol. 2013; 30(1): 67-71

Corresponding Author: Sonay G�ven Karata�, T�rkiye

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Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature

�nsan Ba����kl�k Yetmezlik Vir�s� (HIV) Negatif Human Herpes Virus-8 (HHV- 8) Pozitif Primer Ef�zyon Lenfoma Olgusu ve Literat�r Derlemesi

�nsan Ba��kl�k Yetmezlik Vir�s� (HIV) Negatif Human Herpes Virus-8 (HHV- 8) Pozitif Primer Ef�zyon Lenfoma Olgusu ve Literat�r Derlemesi