Turk J Hematol. 2004; 21(2): 83-86

Effect of plasminogen activator inhibitor-1 4G/5G polymorphism in Turkish deep vein thromboembolic patients with and without prothrombin 20210 G-A

Erkan Yılmaz, Ece Akar, Nejat Akar
Department Of Pediatric Molecular Genetics, Ankara University Medical Faculty, Ankara, Turkey

Prothrombin 20210 G-A mutation is a common factor that predispose to thrombosis. The effect of the mutations in PAI-1 gene on the risk of thrombosis is controversial. We aimed to evaluate the role of these two polymorphisms in Turkish patients with deep vein thrombosis. Although there was no statistically significant difference in patient and control group for the distribution of PAI-1 4G/5G polymorphism in the present study, the risk of thrombosis increased from 3.4 fold to 8.4 in patients carrying PT20210 A and PAI-1 4G.

Keywords: Prothrombin 20210 G-A, PAI-1 4G/5G, Deep vein thrombosis.

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Plazminojen aktivatör inhibitör-1 4G/5G polimorfizminin, protrombin 20210 G-A taşıyan ve taşımayan derin ven tromboembolili Türk hastalarda etkisi

Erkan Yılmaz, Ece Akar, Nejat Akar
Department Of Pediatric Molecular Genetics, Ankara University Medical Faculty, Ankara, Turkey

Tromboza yol açan edinsel mutasyonlar içinde protrombin 20210 G-A en önemlilerindendir. PAI-1 polimorfizminin etkisi ise tartışmalıdır. Biz bu çalışmada, her iki mutasyonun derin ven trombozlu Türk hastalarında etkisini araştırdık. Kontrol grubu ile hasta grubu arasında PAI-1 4G/5G polimorfizm farkı saptanmazken PT20210A ve PAI-1 4G`yi birlikte taşımanın tromboz riskini 3.8`den 8.4 kata arttırdığını gösterdik.

Anahtar Kelimeler: Protrombin 20210 G-A, PAI-1 4G/5G, Derin ven trombozu.

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