E-ISSN: 1308-5263
Prediction of Stem Cell Mobilization Failure in Patients with Hodgkin and Non-Hodgkin Lymphoma [Turk J Hematol]
Turk J Hematol. Ahead of Print: TJH-70104 | DOI: 10.4274/tjh.galenos.2020.2020.0409  

Prediction of Stem Cell Mobilization Failure in Patients with Hodgkin and Non-Hodgkin Lymphoma

Haluk Demiroğlu, Rafiye Çiftçiler, Yahya Büyükaşık, Hakan Göker
Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey

Objective: Autologous stem cell transplantation (ASCT) is a significant and potentially curative treatment modality for patients with relapsed/refractory lymphoma. Insufficient mobilization and harvest of peripheral stem cells can be a major obstacle for performing ASCT. The aim of this study was to evaluate the factors which might influence mobilization failure in patients with lymphoma.
Materials and Methods: Eighty-seven patients with diagnosed non-Hodgkin and Hodgkin lymphoma who underwent stem cell mobilization after at Hacettepe University Medical School, Bone Marrow Transplantation Center, Turkey, between the years of 2000 and 2018 were evaluated.
Results: A total of 87 patients were included in this study. In 66 of 87 patients (75.9%) first mobilization trial was successful. Adequate (≥2 × 106/kg) CD34+ cells were collected at first apheresis in 66 patients (9.5±8.1). In 21 of 87 (24.1%) first mobilization trial was unsuccessful. Therefore, a second mobilization trial was made to these patients with plerixafor (5.5±3.3). The number of CD34+ cell was significantly higher in patients who were successful in the first mobilization (p=0.002).
Conclusion: In conclusion, the success rate of the first mobilization trial was found to be higher in patients with high platelet count before mobilization and patients who received a chemotherapy-based mobilization protocol. In the patients who had mobilization failure for the first trial, plerixafor was used at a later mobilization, and those patients had an adequate amount of stem cells for ASCT. Parameters predicting mobilization failure would let a preemptive, more cost-effective use of such agents during the first mobilization attempt, however risk factors for mobilization failure are still not clear.

Keywords: Hodgkin lymphoma, Non-Hodgkin lymphoma, stem cell mobilization, mobilization failure




Corresponding Author: Hakan Göker, Türkiye


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